TITLE : INTEGRATED MEDICINAL APPROACH TO ALCOHOLIC LIVER DISEASE

SPEECH DELIVERED BY : Dr. SHAJI(Chief ayurvedic physician, Saukhya International Holistic Health Centre)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : SHODHANA THERAPY

SPEECH DELIVERED BY : Dr. S G MANGALANGI(H.O.D Department of PG Studies KCGAMC, Mysore)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : CRITICAL AND INTENSIVE CARE IN AYURVEDA

SPEECH DELIVERED BY : VAIDYA TRILOK DHOPESHWARKAR

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : MINIMUM INVASIVE AYURVEDIC SURGICAL PROCEDURES

SPEECH DELIVERED BY : Dr. PRASANNA N RAO(Principal, SDM College of Ayrveda & Hospital, Hosur, Karnataka)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : RE-ABSORPTION OF LUMBAR INTER VERTEBRAL DISC: A CLINICAL POSSIBILITY THROUGH VASTI CHIKITSA & TREATMENT OF HEPATOCELLULAR CARCINOMA

SPEECH DELIVERED BY : Dr. L MAHADEVAN

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : SETTING UP OF AYUR UNITS IN CORPORATE HOSPITALS & INTEGRATED APPROACH TO DIABETIC CARE

SPEECH DELIVERED BY : Dr. J L N SASTRI

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : INREGRATED MEDICINE & AYURVEDA

SPEECH DELIVERED BY : Dr. PARAMESHWAR(Himalayan Institute of Medical Sciences)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : TREATMENT OF NEUROLOGICAL DISORDERS IN AYURVEDA

SPEECH DELIVERED BY : Dr. G SRINIVASA ACHARYA

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : VALIDATION OF REGIMENTAL THERAPY(UNANI) IN OSTEO ARTHRITIS

SPEECH DELIVERED BY : Dr. SHARIQ ALI KHAN

EVENT : INDO-US SYMPOSIUM ON METHODOLOGY OF RESEARCH IN INDIAN SYSTEMS OF MEDICINE(4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU)

TITLE : SURGICAL TREATMENT IN AYURVEDA FOR ANAL FISTULA

EVENT : INDO-US SYMPOSIUM ON METHODOLOGY OF RESEARCH IN INDIAN SYSTEMS OF MEDICINE(4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU)

TITLE : PRECLINICAL SAFETY STUDY OF AYURVEDIC RAS AUSHADHIS ie; HERBO, METALLIC FORMULATIONS COMMONLY PRACTICED IN ARTHRITIS AND DYSLIPIDEMIA

SPEECH DELIVERED BY : Dr. SURINDER SINGH(Dept. of Pharmacology, AIMS, Delh)

EVENT : INDO-US SYMPOSIUM ON METHODOLOGY OF RESEARCH IN INDIAN SYSTEMS OF MEDICINE(4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU)

TITLE : AN OVERVIEW OF PHARMACEUTICAL SECTOR IN INDIA WITH SPECIAL EMPHASIS ON INDIAN SYSTEMS OF MEDICINE

SPEECH DELIVERED BY : Prof. S S HANDA(Chairperson of the Pharmacopeia Commission for Indian Medicine)

EVENT : INDO-US SYMPOSIUM ON METHODOLOGY OF RESEARCH IN INDIAN SYSTEMS OF MEDICINE(4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU)

TITLE : VALIDATION OF UNANI TREATMENT IN HYPERTENSION

SPEECH DELIVERED BY : NAZIR ANSARI

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : AN OVERVIEW OF AYUSH SECTOR

SPEECH DELIVERED BY : SHRI ANIL KUMAR(Secretary of AYUSH Department, Govt. of India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Watch Anuloma Viloma Pranayama to reduce weight - Baba Ramdev - English. Regular yoga practice can help in weight management and aid you in getting rid of excess calories. Watch Baba Ramdev-ji skillfully guide you through some yogic exercises that will induce more continuous and deeper breathing, as a result of which you will be able to burn fat gradually.

TITLE : ISSUES WITH RAW DRUGS IN CLINICAL PRACTICE OF ISM

SPEECH DELIVERED BY : P U MAHESH(Department of Dravyagunavijnana, Government Ayurveda College, Thripunithura, Kerala, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Dravya, the tool of vaidya for treatment, was given prime importance next to Bishak. Because management of diseases using medicines comprises the major part of treatment in Ayurveda, the word Dravya often employs to symbolize drug. The source of Ayurvedic drugs constitute either plant, animal or mineral origin. However, plant source constitute about 80% of materials used in this line of treatment. Even though the demand for this indigenous system is increasing, Ayurveda is facing challenges from the quality of raw drugs used in treatment. Most of these confronts remain hidden from the awareness of physicians who practice in this fi eld. If there is a lack of positive response in treatment, physicians usually assume that prolong treatment is essential to get result or may be due to wrong diagnosis and wrong selection of treatments, but never think of the quality of raw drugs used in treatment. Recent survey by a central body of India observed that most of the raw drugs used in Ayurvedic medicine are of substandard quality. Hence, this is an attempt to make known the issues that lead to low quality raw drugs which will undeniably slowdown the disease curing process. Defects, such as sophistication, substitution, admixture, deterioration, spoilage, and inferiority, found in a survey conducted on different market samples of raw drugs in different places in India will be discussed in full paper with relevant facts and examples.

TITLE : ROLE OF PEOPLE'S BIODIVERSITY REGISTERS IN CONSERVATION AND SUSTAINABLE USE OF MEDICINAL PLANTS WITH REFERENCE TO DIFFERENT GRAM PANCHAYATS IN BIDAR DISTRICT, KARNATAKA STATE, INDIA

SPEECH DELIVERED BY : S V KALMATH(Department of Botany, Karnataka Arts, Science and Commerce College, Bidar, Karnataka, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Conservation and Sustainable Development were the main agenda of Convention on Biodiversity (CBD) held at Rio de Janerio, Brazil in from 3 to 14 June 1992. Including India, 188 nations were the signatories for the agreement to possess the sovereignty over the bioresources, conservation of biodiversity and sustainable use; equal distribution of the benefit to each country was resolved. India promulgated biodiversity act in 15 April 2002 and passed the biodiversity regulations in 2004 for formation of Biodiversity Management Committee (BMC) at the Gram Panchayat level to serve the purpose of PBR. Preparation of People’s Biodiversity Registers is done through the Biodiversity Management Committee (BMC) in consultation with the local people, nati vaidyas and traditional knowledgeable persons. The register shall contain comprehensive information on the knowledge available on biological resources. The preparation of PBR is a huge task that involves students, teachers and people. The documentation of biodiversity prescription listed will go a long way in proper management, conservation and equitable share benefi ts to local body in addition to providing tool for sustainable use of biodiversity in perpetuity to the benefit of future 124 ABSTRACTS • 4th World Ayurveda Congress and Arogya Expo 2010 Oral Presentation generation. PBR includes project methodology, study place, landscape, waterscape, people scape, life scape, traditional knowledge, developmental plans and management practices. More than 100 persons of different communities and traditional knowledgeable persons depending upon biodiversity, and natural resources directly and indirectly were personally interviewed and the traditional knowledge was documented. More than 300 plant species documented about 100 medicinal plants in wild locality and more than 100 animals known to the local people were documented with their local environmental status through field visits, personal contacts, photographs and videographs. Comprehensive measures were adopted with a view to PBR preparations for future work on biodiversity conservation sustainable use and equitable share benefi ts to the local body. PBR helps, protects the local bioresources and prevents from biosmuggling. The local people get right to equal share distribution from the benefi ts of new type of use of bioresources.

TITLE : USE OF HAIRY ROOT TECHNOLOGY FOR MASS PRODUCTION OF SECONDARY METABOLITES FROM PLANTS

SPEECH DELIVERED BY : NIRODITA PATRA

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Hairy roots (HRs) are obtained by integration of a DNA segment (T-DNA) from the root-inducing (Ri) plasmid of Agrobacterium rhizogenes into the plant genome, which leads to the formation of adventitious roots at the site of transformation. Transformed ‘hairy’ root cultures are a biochemically and genetically stable model for assessing biosynthesis and scale-up of pharmacologically important natural products. The HR culture system is a potential approach for the production of pharmaceuticals, because it has many good traits, such as rapid growth rate, easy culture and genetic manipulation and, most importantly, an increased ability to synthesize useful metabolites that cannot be produced by unorganized cells even higher than plant roots. The greatest advantage of HRs is that they often exhibit about the same or greater biosynthetic capacity for secondary metabolite production when compared with their mother plants. The conditions of transformation (nature and age of the explants, bacterial strain, bacterial density and the protocol of infection) deeply influence the frequency of the transformation events as well as the growth and productivity of the HRs. Optimizing the composition of nutrients for HR cultures is critical to gain a high production of secondary metabolites. Factors such as the carbon source and its concentration, the ionic concentration of the medium, the pH of the medium, light, phytohormones, elicitation by biotic or abiotic stress, temperature and inoculum are known to infl uence growth and secondary metabolism. The demonstration of induction and mass scale propagation of HR cultures in bioreactors for some of the plant metabolites important for traditional medicine will be presented.

TITLE : TISSUE CULTURE STUDIES OF GLYCYRRHIZA GLABRA (LICORICE): AN IMPORTANT MEDICINAL PLANT

SPEECH DELIVERED BY : K S VISHWAKARMA(School of Life Sciences, North Maharashtra University, Jalgaon, Maharashtra, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Licorice (Glycyrrhiza glabra L.) is one of the most important drugs in traditional medicine. It is also useful as a sweetening and fl avouring agent. The use of licorice due to many pharmacological properties is very high and the sources are limited. Attempts were made for callus culture and shoot tip culture of licorice. Combination of NAA and BAP was found to be most suitable for callus induction from leaf explant. Shoot tip cultured on Organized by Vijnana Bharati and Department of AYUSH, Government of India • ABSTRACTS 129 Medicinal Plants MS media supplemented with BAP resulted in multiple shoot production. Subculturing of one of these shoots on half strength M.S. media fortifi ed with BAP resulted in formation of more than 10 shoots. Each shoot was cut and transplanted on a medium containing a combination of IAA and IBA for rooting and subsequently into a whole plant.

TITLE : EFFECT OF IPOMOEA DIGITATA TUBER(KSHEERVIDARI) ON BLOOD PRESSURE AND SOME CORONARY RISK FACTORS IN MAN

SPEECH DELIVERED BY : VARTIKA JAIN(Laboratory of Ethnobotany and Agrostology, Department of Botany, University College of Science, Mohan Lal Sukhadia University, Udaipur, Rajasthan, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

The main objective of this study is to evaluate of Ipomoea digitata Linn. (Ksheervidari) tuber powder for its effect on blood pressure, blood lipids, fibrinolytic activity and total antioxidant status (TAS) in patients with newly diagnosed stage 1 hypertension. Ksheervidari is ethnomedicinally recommended for high blood pressure and heart disease. The present study is its therapeutic validation in patients with hypertension on some coronary risk factors. Fifty newly diagnosed individuals with stage 1 hypertension were randomly categorized into two groups. Group I (n = 30) was administered 3 g of tuber powder in two divided doses for 12 weeks and Group II (n = 20) received matched placebo. Blood pressure was recorded initially and at 4 weeks interval, and fasting blood samples were collected for estimation of lipid profi le, fibrinolysis and TAS. Three gram tuber powder significantly (P < 0.001) decreased systolic, diastolic and mean blood pressure and increased fibrinolytic activity at the end of 12th week. TAS was significantly (P < 0.001) increased by 103%. Serum cholesterol, LDL-C and atherogenic index were also significantly (P < 0.05) reduced at the end of the study. It was tolerated well without any signifi cant side effect. Placebo group, however, did not show significant alteration in any of the parameters. To conclude, Ksheervidari significantly lowers blood pressure and blood lipids, enhances fibrinolysis and improves antioxidant status in stage 1 hypertensive individuals without any side effects.

TITLE : IN VITRO STUDY ON ANTIMUTAGENIC PROPERTY OF VATASHUNGA (LEAF BUDS OF FICUS BENGHALENSIS LINN.) IN FEMALES WITH RECURRENT ABORTIONS

SPEECH DELIVERED BY : K NEETHU SEN(Department of Dravyagunavijnanam, Governement Ayurveda College, Tripunithura, Kerala, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Incidence of abortion in all confirmed pregnancies is probably higher because some very early abortions are mistaken for a late menstrual period. In Ayurveda, the roles of drugs mentioned in pumsavana karmas (to prevent abortions, to determine the sex of child and for the proper development of fetus) have to be revealed for a better interpretation and also to apply it in treatment. Proved antioxidant property of the study drug also gives a clue on its level of action. An in vitro study is undertaken with vatashungam (leaf buds of Ficus benghalensis). The objectives of this study are to evaluate the extent of somatic DNA changes, induced by vatashungam in lymphocytes of females with recurrent abortions and to evaluate the anti-mutagenic activity of vatashungam in human lymphocytes using cytokinesis block micronuclei assay (CBMN). The paper discusses the results of this study.

TITLE : BOMBAX CEIBA ROOT POWDER: A HERBAL 'POLYPILL' FOR PATIENTS WITH INCREASED CARDIOVASCULAR RISK

SPEECH DELIVERED BY : S K VERMA(Indigenous Drug Research Center, Department of Medicine, RNT Medical College, Udaipur, Rajasthan, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

The objective of this study is to evaluate the effect of Bombax ceiba Linn. (Semal) root powder on various coronary risk factors in patients with ischemic heart disease (IHD). Semal root powder is ethnomedicinally recommended for diabetes and heart disease and has components that affect many cardiovascular risk parameters in animal and in in vitro experiments. The study was conducted in two groups of stable IHD patients with or without type 2 diabetes. Group I (n = 20) IHD patients without type 2 diabetes and Group II (n = 15) IHD patients with type 2 diabetes, uncontrolled on OHA. Fasting blood samples were collected both before and after 4, 8 and 12 weeks administration of 3 g of root powder for the estimation of blood sugar, lipid profi le, fibrinogen, fibrinolysis and total antioxidant status (TAS). The results reveal that supplementation of 3 g B. ceiba root powder in Group II demonstrated a significant (P < 0.02) reduction in blood sugar at 4 and 8 weeks. There was a significant decrease (P < 0.05) in fibrinogen and increase in fibrinolytic activity and TAS (P < 0.01 in Group I and P < 0.05 in Group II). Lipid profile improved favorably with reduction in atherogenic index in both the groups. There were no significant side effects. To conclude, the study has for the first time validated scientifically the effect of B. ceiba root on modification of multiple coronary risk parameters in man. It might prove to be a useful ‘natural polypill’ for such vulnerable people.

TITLE : NEED FOR STANDARDIZATION OF TREATMENT APPROACHES IN AYURVEDA AND ITS CHALLENGES

SPEECH DELIVERED BY : G SASHIDHARA(Clinical Registrar, IAIM, Bangalore, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Ayurveda is especially known for its highly individualistic approach in the treatment of diseases. There are several schools of thought in understanding the concepts of Ayurveda and implementation of its principles in clinical practice. In this era of globalization and standardization, there is a dire need to arrive at a consensus in the approach to treatment of diseases in Ayurveda. Standardization is the first step towards globalization. It is an essential tool not only for proper understanding of the pathology, appropriate diagnosis, and treatment, but also for scientific documentation and generating evidence for global acceptance and appreciation among the scientific community. There are several constraints and hurdles incoming at a clear consensus due to our own inhibitions and lack of thorough understanding of the science. This paper aims at bringing out the necessity to standardize treatment approaches and the challenges surrounding the same.

TITLE : POTENTIAL IMPACTS OF GENETIC ENGINEERING ON AYURVEDA

SPEECH DELIVERED BY : JHON FAGAN(Professor of Molecular Biology, Maharishi University of Management, and Chairman and Chief Scientific Officer, Global ID Group, Fairfield, Iowa, USA)

It is well recognized that modern science is very useful to Ayurveda in that it provides effective methods of testing and quality assurance that can and should be used in Ayurveda to assure hygiene, verify authenticity of herbs and ingredients, verify consistency and effectiveness of processing, mixing, inventory management, packaging, distribution, etc. However, in recent years, enthusiasts have been promoting the idea that one very new branch of modern biotechnology, genetic engineering, offers great promise for the future of Ayurveda. It is claimed that genetic engineering can be used to make Ayurveda more effective, profitable, and attractive. A typical claim is that genetic engineering can improve the potency of the medicinal plants used in Ayurveda and thereby bring amplifi ed economic benefits to the developers. This paper explores the accuracy of these claims, considering whether the new and relatively untested technology of genetic engineering will influence Ayurveda positively, or whether it will be damaging to this ancient and time-proven science of health and well-being.

TITLE : TREATMENT OF HEART DISEASES USING SHILAJIT

SPEECH DELIVERED BY : Dr. A V PANATH

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : PHARMACOGENOMICS

SPEECH DELIVERED BY : Dr. K SATHYAMURTHY

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : SAMPURNA HRIDAYA SUDHIKARAN THERAPY; AN AYURVEDIC APPROACH TO IMPROVE THE EXERCISE TOLERANCE IN CHRONIC HEART PATIENTS

SPEECH DELIVERED BY : Dr. ROHIT MADHAV

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : MANAGEMENT OF OSTEOPOROSIS IN β-THALASSAEMIA

SPEECH DELIVERED BY : SAGAR S NARODE(MD Scholar, Department of Rasashastra and Bhaishajya Kalpana, National Institute of Ayurveda, Jaipur, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

With increased life expectancy of thalassaemic patients, osteopenia osteoporosis syndrome (OOS) is a major cause of bone pain of hip and spine and fragility fractures, especially of the lumbar spine. This may be found in 70%–80% of adult patients with β-thalassaemia worldwide, accounting for signifi cant bone morbidity. At Thalassaemia Day Care Centre, SMS Medical College, Jaipur, patients with thalassaemia were observed for associated osteoporotic bone disorder. The commonest presentation observed was bone pain and backache with or without past history of fractures. According to Ayurveda, majja kshaya is the causative factor of this disease. While thinking osteoporosis in patients with thalassaemia, we have to consider more about dhatwagni vikruti rather than merely kshaya. Using various basic principles of formation of dhatu of body, Ayurveda provides the baseline for treating osteoporosis in thalassaemia. Pitta dhara kalaa is also majja dhara kalaa. Hence, the solution for this problem starts from GIT, and also different treatments such as Dhatwagni modification, degeneration prevention, compensating compromised body element through specifi c basti, sneha virechana, vid dravya, dhatu pachak dravya, nutritive supplements and Rasayana for specifi c Dhatu. The logic behind selection of particular line of treatment and the possible regimen for treating osteoporosis in thalassaemia are discussed in detail in this paper.

TITLE : ROLE PF AYURVEDA AND YOGA IN HOLISTIC MANAGEMENT OF MADHUMEHA (DIABETIS MELLITUS) w.s.r TO DIET AND LIFESTYLE

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

The perspective to visualise the management of Madhumeha (DM) has shifted from holistic to drug oriented with the advent of time from ancient to modern. Therefore, till a few years before the revival of the holistic inclusion, the diet and lifestyle were not being much focused on in its management. In order to socially project the wholesome treatment and not just the approach towards the drugs, the present work aimed to evaluate the qualitative extra effect of Ahara and Vihara from the viewpoint of Yoga and Ayurveda in Madhumeha. The selected 23 patients of this study were divided into three groups where Group 1 (Ayurveda and Yoga + Ahara and Vihara) shows a total effect of 83.33% of moderate improvement, while Group 2 (only Ahara and Vihara) shows a 50% effect and Group 3 (only Ayurvedic drug/varadi kwatha) shows 27.23%. A very highly signifi cant result (P < 0.001) was observed in Utsahahani with Alasya and highly signifi cant (P < 0.01) in FBS, PPBS, Pipasaadhikya, Daurbalya of Group 1, while in Group 2 a highly signifi cant result was in FBS, and fi nally in Group 3 a very highly signifi cant result (P < 0.001) was observed in Prabhuta Mutrata, Pipasaadhikya, Pindikovestana, Daurbalya, Alasya with Utsahahani and Klaibya. This paper presents the details of the study.

TITLE : MANAGEMENT OF SHAKASHRITA KAMALA w.s.r VIRAL HEPATITIS-B: AN OBSERVATIONAL STUDY

SPEECH DELIVERED BY : M MAHESH SHARMA(Research Scholar, Department of PG Studies in Kayachikitsa, Government Ayurveda Medical College, Mysore, India)

TITLE : ETIOPATHOGENERSIS OF PARINAMASHOOLA AND ROLE OF ENDOSCOPIC STUDY IN ITS DIAGNOSIS

SPEECH DELIVERED BY : R Y TIMMAPUR(Department of Nidana, K.LE.University, Shri.B.M.K.Ayurveda Mahavidyalaya Post Graduate Studies and Research Centre, Shahapur, Belgaum – 590 003, Karnataka, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

The aims and objectives are to study the clinical observations of Parinama Shoola and to analyse the endoscopic findings and different types of Parinama Shoola. The hypothesis is that the study of Parinama Shoola in the light of endoscopic evaluation is one such method to arrive at precise diagnosis that helps the clinicians for a precise treatment at the earliest. Hence this study is taken. Special proforma is prepared at all points of history-taking and examination with respect to symptoms and signs of Parinama Shoola (APD) are made as mentioned in our classics and allied science. Later these patients are subjected to endoscopic examination to identify the changes in the oesophagus stomach and duodenum. Twenty patients were categorized into groups of different diseases according to endoscopic and clinical findings. In this study, all the 20 patients show some or other endoscopic findings, and this wide range of endoscopic changes itself suggests the necessity of endoscopy to identify the different possibilities of acid peptic disorders which occur in the Parinama Shoola. This endoscopic finding suggests that Parinama Shoola is not a single disease entity, but it is a syndrome.

TITLE : EXPERIENCE WITH INTEGRATING AYURVEDA WITH CONVENTIONAL SYSTEM IN A TERTIARY CARE HOSPITAL FOR MANAGEMENT OF OSTEOARTHRITIS(KNEE): A WHO COLLABORATIVE STUDY

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

The Indian health policy 1983, National population policy 2000, ISM&H Policy 2002 and the National rural health mission (NRHM) are the policy recommendations for mainstreaming of AYUSH. Co-location of AYUSH is a main agenda of NRHM also. In some hospitals, the integration in terms of education, patient care and research is well established, but it is not popularized among health care providers in many other places due to various reasons. Ayurvedic Unit exists in Safdarjung hospital, New Delhi, since 1998, but functional integration in the form of referrals is not so well developed. To study the reasons for this and to create awareness about strength of Ayurveda among the allopathic service providers and the health care seekers through a systematic way, an operational study was conducted in Safdarjung Hospital, New Delhi, in collaboration with the Department of Orthopedics and WHO India offi ce. The study covered 252 patients of osteoarthritis knee with the involvement of 30 orthopedicians in duration of 1 year. For the management of osteoarthritis, Yogaraja Guggul, Ashwagandha and mahanarayana taila were used along with lifestyle and dietary recommendations. The standard assessment criteria (WOMAC score, VAS, QOL, intake of rescue analgesics, adverse events, patients feedback, etc.) were used. The study provided data about the status of functional integration in the hospital, reasons for the lack of cross-referral system, benefits of Ayurvedic procedure for osteoarthritis knee, perception of the patients about the integration, etc. It was evident from the study that the continued communication and scientifi c approaches will ascertain actual integration, and osteoarthritis has good scope for developing integration model. The detailed outcome of the study including clinical data will be presented in the paper.

TITLE : IMPLEMENTATION OF PHARMACOVIGILANCE IN RASAKALPA MANUFACTURING AND PRACTICE

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Rasaushadhies were widely accepted and safely used since long. However, in the current scenario increased demand resulted in adulteration, etc., leading to causation of ADR. In media, negative articles are published regarding metal toxicity where biased samples are used and unnecessarily rasakalpas are targeted. The objective of this study is to implement pharmacovigilance in rasakalpa manufacturing and clinical practice. The hypothesis is that mere GMP, ISO, etc. are not sufficient to control and regulate rasa pharmaceuticals and rasa vaidyakam. For checking the indiscipline, the pharmacovigilance implementation in this sector will be helpful. The manufacturers of Rasaushadhies should strictly follow safety profiles, quality control measures, metal toxicity studies, classical and up to date technological assessments, etc. The practitioners of Ayurveda using Rasaushadhies must be vigilant enough to find out adverse drug reactions, drug interactions and untoward effects if any, when used according to the norms. The results show that pharmacovigilance is required in every field of medical practice. Hence, the prospective observation and information from all corners of India must be collected in the coming years to answer global blame of pseudo metal toxicity. To conclude, pharmacovigilance system should be implemented in national drug regulatory system. The paper presents the full details.

TITLE : SYNDROME-TARGETED AYURVEDIC MANAGEMENT FOR MENOPAUSAL HEALTH

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU

Diverse symptom complexes at menopausal transition and beyond are causally related to estrogen decline and insuffi ciency. Clinical presentation due to this estrogen deficiency may be related to symptom clusters involving different systems viz. neuroendocrine (hot fl ushes, insomnia, anxiety/depression, decline in memory and cognition), urogenital system (urinary frequency, dysuria, dyspareunia, laxvagina), musculoskeletal system (fatigue, joint pains, back-ache and bone pains), cardiometabolic system (weight gain, dyslipidemia, hyperinsulinism and hypertension). Outcome of Women’s Health Initiative studies (WHI) for hormone replacement therapy (HRT) revealed tilting of risk/benefi t ratio showing increase in breast cancer, thrombo-embolism, stroke, gall stones, etc. There is thus a wide therapeutic gap for the management of multiple menopausal health issues (MHI) after the global alarm about HRT. Medicinal plants such as Saraca asoka, Glycyrrhiza glabra, Tinospora cordifolia, Withania somnifera and Pueraria tuberosa have potential in the management of menopausal syndrome. It is thus an opportune time to develop appropriate integrated management approaches for various menopause-related health problems through reverse pharmacology path. The present paper will briefl y review rationale behind specifi c targetrelated selection of medicinal plants.

TITLE : EVALUATION OF KATINDUKA VATI AND NAGARADI CHURNA IN VINCRISTINE-INDUCED PAINFUL NEUROPATHY IN RATS

SPEECH DELIVERED BY : Dr JAGRITI SHARMA (MD Scholar, Department of Ras Shastra and Bhaishajya Kalpana, National Institute of Ayurveda, Jaipur, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU

The present study was designed to investigate the effect of kaktinduka vati and nagaradi churna in vincristine-induced neuropathic pain in rats. The pin prick, cold immersion, hot plate and hot immersion tests were performed to assess the degree of mechanical and cold hyperalgesia, heat hyperalgesia and allodynia, respectively. The nerve thio-barbituric reactive substances (TBARs) and reduced glutathione were measured as the marker of oxidative stress. Kaktinduka vati (4 mg) and nagaradi churna (47 mg) were administered for 21 days after vincristine (50 μg/kg i.p) administration. Administration of kaktinduka vati and nagaradi churna attenuated vincristine-induced mechanical, cold and heat hyperalgesia. Both the drugs also decrease oxidative stress, but amelioration in behavioral parameter is more signifi cant in kaktinduka vati. It may be concluded that kaktinduka vati and nagaradi churna have ameliorative potential in attenuating the painful state associated with vincristine, which may be further attributed to anti-oxidative potential of both formulations.

TITLE : TO STUDY THE EFFICACY OF PUNARNAVADI TAILA MATRA BASTI IN THE MANAGEMENT OF VATAJ HRUDROGA

SPEECH DELIVERED BY : Dr AMIT R NAMPALLIWAR (MD Scholar, Department of Rognidan and V.V., Government Ayurved Hospital, Nanded, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU

Over the year, the heart has become more and more vulnerable to derangement with the result that cardiac disorders have become one among the major killers of the present days in developed and developing countries. Basti chiktsa has been advocated and practiced by Ayurvedic clinicians. Basti chikitsa is the more therapeutic effect than other types of treatments that are used to cure various chronic illnesses. In this context, scientific explanations are highly warranted, establishing the effi cacy of such treatment. The aim and objective of the study was ‘to study the effi cacy of punarnavadi taila matra basti in Vataj Hrudroga’ and to study conceptual aspect of basti karma through Ayurvedic literature. For the study, 60 patients having symptoms of Vataj Hrudroga like Hrudshul (chest pain), Hrudrava (palpitation), Swasawarodha (dyspnea), etc. were selected from IPD and OPD of GAC Nanded. Patients were treated under two groups: Group A (trial group): 30 patients were administrated the matra basti of punaranavadi taila only. Group B (control group): 30 patients on placebo treatment. After the study, it was observed that the relief of symptoms in experimental group was statistically signifi cant, which suggests that punarnavadi tail matra basti is effi cacious in Vataj Hrudroga, and in control group it was observed that no relief in symptoms of Hrudshul, Hruddrava and Shwasawarodha. Also, both the groups showed relief in psychological symptoms like Shoka, Bhaya, etc. No side or toxic effects were noted in any of the patients during the trial period.

TITLE : PRECLINICAL STUDIES OF ANTI-ATHEROSCLEROTIC AND ANTI-DIABETIC POTENTIAL OF AYURVEDIC DRUG MURRAYA KOENIGII LINN. SEEDS AND ITS ISOLATED CRUDE SAPOGENINS IN EXPERIMENTAL RATS

SPEECH DELIVERED BY : Dr AJAY KUMAR SHARMA (Department of Pharmacy, GSVM Medical College, Kanpur, India)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Cardiovascular disease is the number one cause of death globally and is projected to remain the leading cause of death. An estimated 17.5 million people died from cardiovascular disease in 2005, representing 30% of all global deaths. Of these deaths, 7.6 million were due to heart attacks and 5.7 million were due to stroke. Around 80% of these deaths occurred in low- and middle-income countries (LMIC). If appropriate action is not taken, by 2015, an estimated 20 million people will die from cardiovascular disease every year, mainly from heart attacks and strokes. Ethanolic extracts of seeds (100 and 200 mg/ kg bodyweight) of Murraya koenigii as well as sapogenins (10 mg/kg bodyweight) isolated from its seed were investigated for lipid-lowering activity on triton-induced and high fadiet-induced model. Serum lipids were found to be lowered in both models and data were analysed statistically signifi cant. In acute studies of triton-induced model, ethanolic seed extract (100 and 200 mg/kg bodyweight) decreases serum total cholesterol, triglyceride and LDL-cholesterol levels by 29.69% and 36.30%, 48.74% and 54.27%, 40.17% and 53.51%, respectively. While isolated sapogenins (10 mg/kg bodyweight) decrease serum total cholesterol, triglyceride and LDL-cholesterol levels by 29.42%, 39.57% and 43.41%, increase in HDL level in ethanolic extract with the above dose was 5.13% and 9.36%, and in case of sapogenins it was found to be 3.79%. In chronic studies of high fat diet-induced model, ethanolic extract of seeds (100 and 200 mg/kg bodyweight) decreases serum total cholesterol, triglyceride and LDL-cholesterol levels by 41.19% and 47.92%, 31.15% and 39.85%, 58.79% and 68.18%. In case of sapogenins (10 mg/kg body weight), decrease was 47.91%, 32.09% and 71.63%. Increase in the level of HDL-cholesterol level in ethanolic extract (100 and 200 mg/kg body weight) and sapogenins (10 mg/kg body weight) was found to be 62.43%, 73.92% and 82.18%, respectively. The seed  extract of M. koenigii not only decreases lipid profi le but also decreases the value of serum glucose in the same dosage regimen as 21.54% and 27.48%, and its sapogenin decreases the level as 20.49%. Our study also revealed that the sapogenins are major contributor of the observed lipid lowering activity as well as antidiabetic activity, and thus may be suitable drug candidates worthy of pharmaceutical investigation.

TITLE : UTILITY OF CONTEMPORARY AND ANCIENT CONCEPTS OF PHARMACOVIGILANCE IN AYURVEDA

SPEECH DELIVERED BY : Dr. NEELAKANTA J SAJJANAR(PG Scholar, Department of PG Studies in Kaya Chikitsa, ALN Rao Memorial Ayurvedic Medical College,Koppa)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

TITLE : EVALUATION OF THE ANTI-HYPERDEMIC ACTIVITY OF ORYZANOL, ISOLATED FROM CRUDE RICE BRAN OIL, ON TRITON WR - 1339 - IINDUCED HYPERLIPIDEMIA IN RATS

SPEECH DELIVERED BY : Dr.S B GHATAK (Department of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad)

EVENT : 4th WORLD AYURVEDA CONGRESS, 2010, BENGALURU.

Experimental studies carried out for evaluating the anti-hyperlipidemic properties of rice bran components have given interesting but often contrasting results. The objectives of this study are to develop and optimize a simple technique for isolating oryzanol, a commercially important bioactive phytochemical from crude rice bran oil (cRBO), followed by the evaluation of its anti-hyperlipidemic activity. Oryzanol was isolated by a two-step solvent crystallization process from cRBO, which was extracted from fresh rice bran by hexane-mediated soxhlet extraction. Subsequently, oryzanol (100 and 300 mg/kg. p.o.) was evaluated for anti-hyperlipidemic activity in Triton WR-1339-induced acute hyperlipidemic albino rats by estimating serum triglyceride, phospholipids, total cholesterol, very low density lipids (VLDL), low-density lipids (LDL) and high-density lipid (HDL) levels with atorvastatin as the reference standard. The degree of protection was also assessed by measuring the levels of various hepatic antioxidant  enzymes. The results show that oryzanol evoked a signifi cant decrease in the levels of serum cholesterol, phospholipids, triglycerides, LDL and VLDL, and a signifi cant increase in the level of serum HDL and hepatic antioxidant enzymes. It also showed a signifi cant ameliorative action on elevated atherogenic index (AI) and LDL/HDL-C ratios. To conclude, these fi ndings indicate that oryzanol possesses the potential to lower plasma lipid concentrations and might be of therapeutic benefi t in hyperlipidemia and atherosclerosis.